Mission Hills, CA Mission Hills is an urban residential community of the San Fernando Valley, within the city of Los Angeles, California. It is near the northern junction of the Golden State Freeway (I-5) and the San Diego Freeway (I-405). The Ronald Reagan Freeway (SR-118) halves the community. Mission Hills is at the northern end of the long Sepulveda Boulevard. It includes the Andrés Pico Adobe, the second oldest residence still standing in Los Angeles. The San Fernando Mission Cemetery, located a short distance away, is one of the oldest active cemeteries within the San Fernando Valley.